FOR APPROPRIATE COVID-19 PATIENTS AT HIGH RISK FOR PROGRESSION TO SEVERE ILLNESS,
INITIATE ORAL TREATMENT
WITHIN 5 DAYS OF SYMPTOM ONSET
Developed by Pfizer Inc.
The progression of COVID-191,2
Early in the course of disease, patients may experience mild symptoms as SARS-CoV-2 replicates. In many patients, the immune system responds and prevents the virus from spreading. But in patients who develop severe illness, an abnormal immune response occurs, leading to respiratory and even systemic inflammation.
Early Infection2,3
Pulmonary Response2,3
Hyperinflammation2,3
Early Infection2,3
Median 4-5 days
Mild symptoms, fever, dry cough, anosmia, dysgeusia
Pulmonary Response2,3
Median 5-8 days
Shortness of breath, with or without hypoxia
Hyperinflammation2,3
Median 8-12 days
Systemic inflammatory response syndrome, cytokine storm, acute respiratory distress syndrome, shock, cardiac failure
moderate
illness
illness
illness
Educate your high-risk patients before they get COVID-19 so they understand their:4,5,6-8
Click to explore
Risk
for severe illness
Importance
of testing quickly if they experience symptoms
Source
of testing and care
Knowing
if they are appropriate candidates for authorized or approved treatment options
Help patients recognize if they're at high risk for progression to severe COVID-193†
Three important factors to consider are
Age, Race & Ethnicity, and Vaccination Status
Studies have shown that COVID-19 does not affect all populations equally. Age is the strongest risk factor for progressing to severe COVID-19. Additionally, the COVID-19 pandemic has highlighted racial, ethnic, and socioeconomic disparities in COVID-19 illnesses, hospitalizations, and deaths. This is due to multiple factors, including barriers to accessing health care.
Looking for a comprehensive list of COVID-19 symptoms?
Footnotes
†Summary of conditions with evidence based on what has been reported in the literature at the time of CDC review. Definitions for each group of medical conditions with evidence can be found at https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-care/underlyingconditions.html
‡Complete list of disabilities from CDC's systematic review process can be found at https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-care/underlyingconditions.html
BMI=body mass index; COPD=chronic obstructive pulmonary disease; HIV=human immunodeficiency virus.
Underlying medical conditions associated
with higher risk for severe COVID-193
